Life on the edge: Telomeres and persistent dna breaks converge at the nuclear periphery

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25 Scopus citations

Abstract

Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double- strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.

Original languageEnglish (US)
Pages (from-to)1027-1031
Number of pages5
JournalGenes and Development
Volume23
Issue number9
DOIs
StatePublished - May 1 2009

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • 3C
  • Chromatin
  • DNA double-strand break
  • DNA repair
  • Mps3p
  • Rad52

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