Liver transplantation before 1 year of age

Carlos O. Esquivel, Baburao Koneru, Frederick Karrer, Satoru Todo, Shunzaburo Iwatsuki, Robert D. Gordon, Leonard Makowka, Wallis J. Marsh, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Since 1981, 20 infants younger than 1 year of age received 26 orthotopic liver transplants. Immunosuppression was with cyclosporine and corticosteroids. Thirteen (65%) of the reciplents were discharged from the hospital. To date, 12 (60%) of the 20 reciplents are surviving, with follow-up of 1 to 56 months (average 14 months). The 5-year acluarial survival is 53.8%. The allograft liver function in the majority of surviving infants is excellent. The predominant causes of mortality were primary nonfunction of the allograft (three patients) and sepsis (three). Major morbidity was caused by hepatic artery thrombosis (five patients), gastrointestinal complications (six), biliary tract complications (five), and bacterial and viral infections (13). Six patients underwent retransplantation; three of these six survived. Results could be improved by prevention of hepatic artery thrombosis, by decreasing the incidence of sepsis, and by procurement of more and better suited pediatric donors.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalThe Journal of Pediatrics
Volume110
Issue number4
DOIs
StatePublished - Apr 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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