Local adjuvants for benign aggressive bone tumors

Benign aggressive bone tumors include giant cell tumors, chondroblastomas, unicameral bone cysts, and aneurysmal bone cysts. They are neoplasms that rarely metastasize but may be locally aggressive and frequently recur. Treatment formerly included wide resection but now increasingly involves curettage to preserve the involved limb and prevent surgical complications. Local adjuvants are used to expand the zone of tumor death and lower recurrence rates. Here, local adjuvants are discussed, including their mechanism, use in studies, and related complications.