Local opiate withdrawal in locus coeruleus in vivo

G. Aston-Jones, H. Hirata, H. Akaoka

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Hyperactivity of noradrenergic locus coeruleus (LC) neurons following withdrawal from chronic opiates has been implicated in the opiate withdrawal syndrome. Here, we report that local withdrawal induced in vivo by microinfusion of an opiate antagonist into the LC of morphine-dependent rats marginally, but significantly, activated LC neurons above the level obtained with local naloxone microinfusion in naive rats. This local withdrawal response contributes a significant fraction (~ 19%) of the total LC hyperactivity induced by systemic naloxone.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalBrain research
Issue number2
StatePublished - Aug 15 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • Electrophysiology
  • Excitatory amino acid
  • Locus coeruleus
  • Norepinephrine
  • Opiate withdrawal

Fingerprint Dive into the research topics of 'Local opiate withdrawal in locus coeruleus in vivo'. Together they form a unique fingerprint.

Cite this