Local vanadium release from a calcium sulfate carrier accelerates fracture healing

David N. Paglia, Aaron Wey, Jeremy Hreha, Andrew G. Park, Catherine Cunningham, Linda Uko, Joseph Benevenia, J. Patrick O'Connor, Sheldon S. Lin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


This study evaluated the efficacy of using calcium sulfate (CaSO 4) as a carrier for intramedullary delivery of an organic vanadium salt, vanadyl acetylacetonate (VAC) after femoral fracture. VAC can act as an insulin-mimetic and can be used to accelerate fracture healing in rats. A heterogenous mixture of VAC and CaSO4 was delivered to the fracture site of BB Wistar rats, and mechanical testing, histomorphometry, micro-computed tomography (micro-CT) were performed to measure healing. At 4 weeks after fracture, maximum torque to failure, effective shear modulus, and effective shear stress were all significantly higher (p < 0.05) in rats treated with 0.25 mg/kg VAC-CaSO4 as compared to carrier control rats. Histomorphometry found a 71% increase in percent cartilage matrix (p < 0.05) and a 64% decrease in percent mineralized tissue (p < 0.05) at 2 weeks after fracture in rats treated with 0.25 mg/kg of VAC-CaSO4. Micro-CT analyses at 4 weeks found a more organized callus structure and higher trending maximum connected z-ray. fraction for VAC-CaSO4 groups. Evaluation of radiographs and serial histological sections at 12 weeks did not show any evidence of ectopic bone formation. As compared to previous studies, CaSO 4 was an effective carrier for reducing the dose of VAC required to accelerate femoral fracture healing in rats.

Original languageEnglish (US)
Pages (from-to)727-734
Number of pages8
JournalJournal of Orthopaedic Research
Issue number5
StatePublished - May 2014

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine


  • BB Wistar rat
  • bone regeneration
  • calcium sulfate
  • fracture healing
  • vanadium


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