Location and arrangement of genes coding for ribosomal RNA in Saccharomyces cerevisiae

David B. Kaback; Madhu M. Bhargava; Harlyn O. Halvorson

doi:10.1016/0022-2836(73)90076-4

Location and arrangement of genes coding for ribosomal RNA in Saccharomyces cerevisiae

David B. Kaback, Madhu M. Bhargava, Harlyn O. Halvorson

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The 140 genes for ribosomal RNA (rDNA) in Saccharomyces cerevisiae occur in clusters of from 10 to 30 cistrons. Approximately 84 rDNA genes have been mapped to chromosome I by comparing the amount of rDNA in a strain monosomic (2n - 1) for chromosome I with a related diploid (2n) strain. The monosomic strain showed an approximate 30% decrease from the diploid in both the amount of heavy satellite DNA and the amount of hybridizable rRNA. It is proposed that three to ten clusters of rDNA are located throughout chromosome I.

Original language	English (US)
Pages (from-to)	735-739
Number of pages	5
Journal	Journal of molecular biology
Volume	79
Issue number	4
DOIs	https://doi.org/10.1016/0022-2836(73)90076-4
State	Published - Oct 5 1973
Externally published	Yes

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

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10.1016/0022-2836(73)90076-4

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title = "Location and arrangement of genes coding for ribosomal RNA in Saccharomyces cerevisiae",

abstract = "The 140 genes for ribosomal RNA (rDNA) in Saccharomyces cerevisiae occur in clusters of from 10 to 30 cistrons. Approximately 84 rDNA genes have been mapped to chromosome I by comparing the amount of rDNA in a strain monosomic (2n - 1) for chromosome I with a related diploid (2n) strain. The monosomic strain showed an approximate 30% decrease from the diploid in both the amount of heavy satellite DNA and the amount of hybridizable rRNA. It is proposed that three to ten clusters of rDNA are located throughout chromosome I.",

author = "Kaback, {David B.} and Bhargava, {Madhu M.} and Halvorson, {Harlyn O.}",

note = "Funding Information: The authors are grateful to Dr Susan Henry for valuable discussions and to Dr Jeremy Bruenn for strain X1221a-{\textquoteleft}7~. This work was supported by a research grant (VC-106B) from the American Cancer Society. One of the authors (D. B. K.) is supported by a National Institutes of Health Predoctoral Training Grant (GM 1586).",

year = "1973",

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doi = "10.1016/0022-2836(73)90076-4",

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T1 - Location and arrangement of genes coding for ribosomal RNA in Saccharomyces cerevisiae

AU - Kaback, David B.

AU - Bhargava, Madhu M.

AU - Halvorson, Harlyn O.

N1 - Funding Information: The authors are grateful to Dr Susan Henry for valuable discussions and to Dr Jeremy Bruenn for strain X1221a-‘7~. This work was supported by a research grant (VC-106B) from the American Cancer Society. One of the authors (D. B. K.) is supported by a National Institutes of Health Predoctoral Training Grant (GM 1586).

PY - 1973/10/5

Y1 - 1973/10/5

N2 - The 140 genes for ribosomal RNA (rDNA) in Saccharomyces cerevisiae occur in clusters of from 10 to 30 cistrons. Approximately 84 rDNA genes have been mapped to chromosome I by comparing the amount of rDNA in a strain monosomic (2n - 1) for chromosome I with a related diploid (2n) strain. The monosomic strain showed an approximate 30% decrease from the diploid in both the amount of heavy satellite DNA and the amount of hybridizable rRNA. It is proposed that three to ten clusters of rDNA are located throughout chromosome I.

AB - The 140 genes for ribosomal RNA (rDNA) in Saccharomyces cerevisiae occur in clusters of from 10 to 30 cistrons. Approximately 84 rDNA genes have been mapped to chromosome I by comparing the amount of rDNA in a strain monosomic (2n - 1) for chromosome I with a related diploid (2n) strain. The monosomic strain showed an approximate 30% decrease from the diploid in both the amount of heavy satellite DNA and the amount of hybridizable rRNA. It is proposed that three to ten clusters of rDNA are located throughout chromosome I.

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Location and arrangement of genes coding for ribosomal RNA in Saccharomyces cerevisiae

Abstract

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