Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22

Linda M. Brzustowicz, Kathleen A. Hodgkinson, Eva W.C. Chow, William G. Honer, Anne S. Bassett

Research output: Contribution to journalArticlepeer-review

419 Scopus citations

Abstract

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide stan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

Original languageEnglish (US)
Pages (from-to)678-682
Number of pages5
JournalScience
Volume288
Issue number5466
DOIs
StatePublished - Apr 28 2000

All Science Journal Classification (ASJC) codes

  • General

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