Locus dependence in epigenetic chromatin silencing

Swagatam Mukhopadhyay, Vijayalakshmi H. Nagaraj, Anirvan M. Sengupta

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalBioSystems
Volume102
Issue number1
DOIs
StatePublished - Oct 2010

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • Applied Mathematics

Keywords

  • Bistability
  • Epigenetics
  • Silencing

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