Locus dependence in epigenetic chromatin silencing

Swagatam Mukhopadhyay; Vijayalakshmi H. Nagaraj; Anirvan M. Sengupta

doi:10.1016/j.biosystems.2010.07.012

Locus dependence in epigenetic chromatin silencing

Swagatam Mukhopadhyay, Vijayalakshmi H. Nagaraj, Anirvan M. Sengupta

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	BioSystems
Volume	102
Issue number	1
DOIs	https://doi.org/10.1016/j.biosystems.2010.07.012
State	Published - Oct 2010

All Science Journal Classification (ASJC) codes

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Applied Mathematics

Keywords

Bistability
Epigenetics
Silencing

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10.1016/j.biosystems.2010.07.012

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title = "Locus dependence in epigenetic chromatin silencing",

abstract = "Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.",

keywords = "Bistability, Epigenetics, Silencing",

author = "Swagatam Mukhopadhyay and Nagaraj, {Vijayalakshmi H.} and Sengupta, {Anirvan M.}",

note = "Funding Information: We acknowledge useful discussions with James Broach, Adel Dayarian and Marc Gartenberg. We also thank the Broach lab for providing strains for our experimental investigations. This work was partially supported by an NHGRI Grant No. R01 HG03470-02.",

year = "2010",

month = oct,

doi = "10.1016/j.biosystems.2010.07.012",

language = "English (US)",

volume = "102",

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T1 - Locus dependence in epigenetic chromatin silencing

AU - Mukhopadhyay, Swagatam

AU - Nagaraj, Vijayalakshmi H.

AU - Sengupta, Anirvan M.

N1 - Funding Information: We acknowledge useful discussions with James Broach, Adel Dayarian and Marc Gartenberg. We also thank the Broach lab for providing strains for our experimental investigations. This work was partially supported by an NHGRI Grant No. R01 HG03470-02.

PY - 2010/10

Y1 - 2010/10

N2 - Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.

AB - Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.

KW - Bistability

KW - Epigenetics

KW - Silencing

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SP - 49

EP - 54

JO - Currents in modern biology

JF - Currents in modern biology

IS - 1

ER -

Locus dependence in epigenetic chromatin silencing

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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