Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

George C. Wagner, George A. Ricaurte, Lewis S. Seiden, Charles R. Schuster, Richard J. Miller, John Westley

Research output: Contribution to journalArticlepeer-review

465 Scopus citations

Abstract

Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalBrain research
Volume181
Issue number1
DOIs
StatePublished - Jan 6 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • catecholamines
  • dopamine
  • methamphetamine
  • toxicity
  • uptake kinetics

Fingerprint Dive into the research topics of 'Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine'. Together they form a unique fingerprint.

Cite this