Long noncoding RNAs: Central to nervous system development

Ronald P. Hart, Loyal A. Goff

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


The development of the central nervous system (CNS) is a complex orchestration of stem cells, transcription factors, growth/differentiation factors, and epigenetic control. Noncoding RNAs have been identified, classified, and studied for their functional roles in many systems including the CNS. In particular, the class of long noncoding RNAs (lncRNAs) has generated both enthusiasm and skepticism due to the unexpected discovery, the diversity of mechanisms, and the lower level of expression than found in protein-coding RNAs. Here we describe evidence supporting the role of lncRNAs in driving CNS-specific differentiation. It is clear that lncRNAs exhibit a functional diversity that makes their study and compartmentalization more challenging than other classes of noncoding RNAs. We predict, however, that lncRNAs will be essential for the characterization of discrete neuronal cell types in the age of single-cell transcriptomics and that these regulatory RNAs contribute to the multitude of functional mechanisms during CNS differentiation that will rival the diversities of protein-based mechanisms.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalInternational Journal of Developmental Neuroscience
StatePublished - Dec 1 2016

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology


  • Differentiation
  • Micropeptides
  • Neurogenesis
  • Noncoding RNA
  • Transcription
  • Transcriptome


Dive into the research topics of 'Long noncoding RNAs: Central to nervous system development'. Together they form a unique fingerprint.

Cite this