Long-term effect of inflammatory mediators on hepatic function

Research output: Contribution to journalConference articlepeer-review


The goal of this study is to investigate the effect of chronic exposure to inflammatory mediators on cultured hepatocytes as a model of inflammation-induced hepatic dysfunction. A collagen sandwich culture model capable of preserving liverspecific functions of adult rat hepatocytes for 6-8 weeks is used. Briefly, exposure to IL-1beta suppressed hepatocytes protein synthesis as measured by albumin and fibrinogen secretion. IL-6 initially suppressed albumin synthesis, but the effect gradually wore off after 2 weeks despite the continuous exposure. Combination of IL-1beta and IL-6 showed same result as IL-1beta alone suggesting that the inhibitory effect of IL-1beta dominated over any effects of IL-6. IL-1beta and IL-6 caused suppression of urea production.

Original languageEnglish (US)
Pages (from-to)S-82
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering


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