Long-term effects of antihypertensive treatment and good glycemic control on plasma lipids in diabetic rats

Alluru Reddi, G. N. Jyothirmayi, J. S. Bollineni

Research output: Contribution to journalArticlepeer-review

Abstract

The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) cholesterol, and decreased levels of high-density lipoprotein (HDL) cholesterol than in normal rats. Compared to other antihypertensives, nicardipine seems to have a less beneficial effect on lipids and lipoproteins. However, it is only the good glycemic control that normalized these plasma lipids and lipoproteins in diabetic rats. This suggests that good glycemic control prevents dyslipidemia in diabetic rats. The observed beneficial effects of antihypertensives were unrelated to either food or water intake.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalJournal of Diabetes and Its Complications
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Long-term effects of antihypertensive treatment and good glycemic control on plasma lipids in diabetic rats'. Together they form a unique fingerprint.

Cite this