Long-term effects of repeated methylamphetamine administration on monoamine neurons in the rhesus monkey brain

Kenzie L. Preston, George C. Wagner, Charles R. Schuster, Lewis S. Seiden

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Previous studies indicate that the repeated administration of d-methylamphetamine (MA) produces a long-lasting depletion of dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) in various brain regions of a number of species. The objectives of the present study were: (1) to establish a short, subcutaneous injection regimen which would reliably produce the neuronal alterations; (2) to evaluate MA-induced NE depletions produced by this new regimen; and (3) to determine whether central MA-induced neuronal changes are reflected in changes in cerebrospinal fluid monoamine metabolite concentrations. It was observed that high doses of MA administered (s.c) over a 2-week period to rhesus monkeys decreases in DA and 5-HT, but not NE levels, in various brain regions. The decrease in caudate DA levels was accompanied by a decrease in the number of DA uptake sites, a decrease in the level of homovanillic acid (HVA) and an increase in DA turnover. This decrease in brain DA was accompanied by a decrease in the cerebrospinal fluid concentration of HVA.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalBrain research
Volume338
Issue number2
DOIs
StatePublished - Jul 15 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • cerebrospinal fluid
  • dopamine
  • methylamphetamine
  • rhesus monkeys
  • serotonin
  • toxicity

Fingerprint Dive into the research topics of 'Long-term effects of repeated methylamphetamine administration on monoamine neurons in the rhesus monkey brain'. Together they form a unique fingerprint.

Cite this