Long-term follow-up of voluntary ingestion of Helicobacter pylori

A. J. Morris, M. R. Ali, G. I. Nicholson, G. I. Perez-Perez, M. J. Blaser

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


After ingestion of Helicobacter pylori, a volunteer developed chronic infection, persistent gastritis, and seroconversion to H. pylori antigens. Single-agent therapies suppressed, but did not eradicate, infection, inflammation, and serologic response. Immunoglobulin M seroconversion followed both primary and recurrent infection. With triple-agent therapy, begun on day 966, H. pylori infection was resolved, gastritis was eliminated, and serologic values were normalized. Follow-up for 2 further years has not shown the recurrence of infection. This case illustrates the natural history, pathology, serology, and response to therapy of H. pylori infection.

Original languageEnglish (US)
Pages (from-to)662-663
Number of pages2
JournalAnnals of internal medicine
Issue number8
StatePublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


  • Bismuth subcitrate
  • Gastritis
  • Helicobacter pylori
  • Metronidazole
  • Tetracycline


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