Long term remissions with combined modality therapy for advanced Hodgkin's disease

Leonard R. Prosnitz, Leonard R. Farber, James J. Fischer, Joseph Bertino, Diana B. Fischer

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


A new treatment program for advanced Hodgkin's disease employing five‐drug combination chemotherapy and low dose radiation to the sites of bulk disease (nodal or parenchymal) was designed in 1969. Eighty patients have now been treated, 60 of whom have achieved a complete remission. More significantly, only 5 of the 60 complete responders have relapsed with followup from 1–6 years. The cumulative survival at 5 years of patients entering complete remission is 92%. For those patients not sustaining a complete remission, it is 19% at 2 years. This program has resulted in substantially lower relapse rates than previously reported by other investigators, probably because of the administration of radiotherapy in the manner described. Hopefully, a significant number of these patients may be cured of their disease.

Original languageEnglish (US)
Pages (from-to)2826-2833
Number of pages8
Issue number6
StatePublished - Jun 1976

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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