Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women

Xuemei Sui, Mark A. Sarzynski, Duck chul Lee, Carl J. Lavie, Jiajia Zhang, Peter F. Kokkinos, Jonathan Payne, Steven N. Blair

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Most of the existing literature has linked a baseline cardiorespiratory fitness or change between baseline and one follow-up measurement of cardiorespiratory fitness to hypertension. The purpose of the study is to assess the association between longitudinal patterns of cardiorespiratory fitness changes with time and incident hypertension in adult men and women. Methods Participants were aged 20 to 82 years, were free of hypertension during the first 3 examinations, and received at least 4 preventive medical examinations at the Cooper Clinic in Dallas, Texas, from 1971 to 2006. They were classified into 1 of 5 groups based on all of the measured cardiorespiratory fitness values (in metabolic equivalents) during maximal treadmill tests. Logistic regression was used to compute odds ratios and 95% confidence intervals. Results Among 4932 participants (13% women), 1954 developed hypertension. After controlling for baseline potential confounders, follow-up duration, and number of follow-up visits, odds ratios (95% confidence intervals) for hypertension were 1.00 for the decreasing group (referent), 0.64 (0.52-0.80) for the increasing group, 0.89 (0.70-1.12) for the bell-shape group, 0.78 (0.62-0.98) for the U-shape group, and 0.83 (0.69-1.00) for the inconsistent group. The general pattern of the association was consistent regardless of participants' baseline cardiorespiratory fitness or body mass index levels. Conclusions An increasing pattern of cardiorespiratory fitness provides the lowest risk of hypertension in this middle-aged relatively healthy population. Identifying specific pattern(s) of cardiorespiratory fitness change may be important for determining associations with comorbidity, such as hypertension.

Original languageEnglish (US)
Pages (from-to)469-476.e2
JournalAmerican Journal of Medicine
Volume130
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Hypertension
Odds Ratio
Metabolic Equivalent
Confidence Intervals
Cardiorespiratory Fitness
Exercise Test
Comorbidity
Body Mass Index
Logistic Models
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Exercise capacity
  • High blood pressure
  • Prevention

Cite this

Sui, Xuemei ; Sarzynski, Mark A. ; Lee, Duck chul ; Lavie, Carl J. ; Zhang, Jiajia ; Kokkinos, Peter F. ; Payne, Jonathan ; Blair, Steven N. / Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women. In: American Journal of Medicine. 2017 ; Vol. 130, No. 4. pp. 469-476.e2.
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abstract = "Background Most of the existing literature has linked a baseline cardiorespiratory fitness or change between baseline and one follow-up measurement of cardiorespiratory fitness to hypertension. The purpose of the study is to assess the association between longitudinal patterns of cardiorespiratory fitness changes with time and incident hypertension in adult men and women. Methods Participants were aged 20 to 82 years, were free of hypertension during the first 3 examinations, and received at least 4 preventive medical examinations at the Cooper Clinic in Dallas, Texas, from 1971 to 2006. They were classified into 1 of 5 groups based on all of the measured cardiorespiratory fitness values (in metabolic equivalents) during maximal treadmill tests. Logistic regression was used to compute odds ratios and 95{\%} confidence intervals. Results Among 4932 participants (13{\%} women), 1954 developed hypertension. After controlling for baseline potential confounders, follow-up duration, and number of follow-up visits, odds ratios (95{\%} confidence intervals) for hypertension were 1.00 for the decreasing group (referent), 0.64 (0.52-0.80) for the increasing group, 0.89 (0.70-1.12) for the bell-shape group, 0.78 (0.62-0.98) for the U-shape group, and 0.83 (0.69-1.00) for the inconsistent group. The general pattern of the association was consistent regardless of participants' baseline cardiorespiratory fitness or body mass index levels. Conclusions An increasing pattern of cardiorespiratory fitness provides the lowest risk of hypertension in this middle-aged relatively healthy population. Identifying specific pattern(s) of cardiorespiratory fitness change may be important for determining associations with comorbidity, such as hypertension.",
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Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women. / Sui, Xuemei; Sarzynski, Mark A.; Lee, Duck chul; Lavie, Carl J.; Zhang, Jiajia; Kokkinos, Peter F.; Payne, Jonathan; Blair, Steven N.

In: American Journal of Medicine, Vol. 130, No. 4, 01.04.2017, p. 469-476.e2.

Research output: Contribution to journalArticle

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N2 - Background Most of the existing literature has linked a baseline cardiorespiratory fitness or change between baseline and one follow-up measurement of cardiorespiratory fitness to hypertension. The purpose of the study is to assess the association between longitudinal patterns of cardiorespiratory fitness changes with time and incident hypertension in adult men and women. Methods Participants were aged 20 to 82 years, were free of hypertension during the first 3 examinations, and received at least 4 preventive medical examinations at the Cooper Clinic in Dallas, Texas, from 1971 to 2006. They were classified into 1 of 5 groups based on all of the measured cardiorespiratory fitness values (in metabolic equivalents) during maximal treadmill tests. Logistic regression was used to compute odds ratios and 95% confidence intervals. Results Among 4932 participants (13% women), 1954 developed hypertension. After controlling for baseline potential confounders, follow-up duration, and number of follow-up visits, odds ratios (95% confidence intervals) for hypertension were 1.00 for the decreasing group (referent), 0.64 (0.52-0.80) for the increasing group, 0.89 (0.70-1.12) for the bell-shape group, 0.78 (0.62-0.98) for the U-shape group, and 0.83 (0.69-1.00) for the inconsistent group. The general pattern of the association was consistent regardless of participants' baseline cardiorespiratory fitness or body mass index levels. Conclusions An increasing pattern of cardiorespiratory fitness provides the lowest risk of hypertension in this middle-aged relatively healthy population. Identifying specific pattern(s) of cardiorespiratory fitness change may be important for determining associations with comorbidity, such as hypertension.

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