Longitudinal stability of medication adherence among adolescent solid organ transplant recipients

Kristin A. Loiselle, Ana M. Gutierrez-Colina, Cyd K. Eaton, Laura E. Simons, Katie A. Devine, Laura L. Mee, Ronald L. Blount

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Solid organ transplantation requires ongoing adherence to immunosuppressants and other medications. Although adolescence is a risk factor for poor medication-taking, little is known about the patterns of adherence within individuals over time. This study aimed to examine the stability of adherence over time using three different assessment techniques. Sixty-six AYA transplant recipients and/or their caregiver completed interviews of adherence at baseline and at least one yr later. Serum immunosuppressant assay levels were collected via medical chart review. Non-adherence percentages based on AYA report, caregiver report, and bioassay did not differ from Time 1 to Time 2. However, correlations for these measures across time were non-significant. Further, the majority of AYAs shifted to a different adherence category from Time 1 to Time 2. Overall, these results demonstrate individual variability in non-adherence over the course of adolescence and young adulthood and highlight the importance of frequent assessment across time for solid organ transplant recipients.

Original languageEnglish (US)
Pages (from-to)428-435
Number of pages8
JournalPediatric Transplantation
Volume19
Issue number4
DOIs
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Keywords

  • adherence
  • adolescents
  • solid organ transplantation

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