Loss of heterozygosity for chromosome 14q in neuroblastoma

John M. Maris, Chun Guo, David Blake, Peter S. White, Michael D. Hogarty, Patricia M. Thompson, Vasanthi Rajalingam, Robert Gerbing, Daniel O. Stram, Katherine K. Matthay, Robert C. Seeger, Garrett M. Brodeur, T. C. Matise

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Background. Neuroblastoma is a genetically heterogeneous disease, with subsets of tumors demonstrating rearrangements of several genomic regions. Preliminary studies from several groups have identified loss of heterozygosity (LOH) for the long arm of chromosome 14 (14q) in 20-25% of primary neuroblastomas. Procedure. To determine precisely the frequency and extent of 14q deletions, we performed LOH analysis for a large series of primary neuroblastomas using a panel of 11 highly polymorphic markers. Results. LOH was detected in 83 of 372 tumors (22%). Although the majority of tumors with allelic loss demonstrated allelic loss for all informative markers, 13 cases showed LOH for only a portion of 14q. A single consensus region of deletion, which was shared by all tumors with 14q LOH, was defined within 14q23-q32 between D145588 and the 14q telomere. Allelic loss for 14q was strongly correlated with the presence of 11q LOH (P < 0.001) and inversely correlated with MYCN amplification (P = 0.04). Conclusions. LOH for 14q was evident in all clinical risk groups, indicating that this abnormality may be a universal feature of neuroblastoma tumor development. These findings suggest that a tumor suppressor gene involved in the initiation or progression of neuroblastoma is located within distal 14q.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalMedical and Pediatric Oncology
Volume36
Issue number1
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Keywords

  • Chromosome deletion
  • Chromosomes
  • Cultured tumor cells
  • Human
  • Loss of heterozygosity
  • Neuroblastoma
  • Pair 14
  • Prognosis
  • Tumor suppressor genes

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