Low CD4+ T-lymphocyte values in human immunodeficiency virus-negative adults in Botswana

Hermann Bussmann, C. William Wester, Kereng V. Masupu, Trevor Peter, Sarah M. Gaolekwe, Soyeon Kim, Ann Marie Reich, Sam Ahn, Ying Wu, Ibou Thior, Max Essex, Richard Marlink

Research output: Contribution to journalArticle

27 Scopus citations


CD4+-lymphocyte counts (LCs) play a crucial role in the management and monitoring of HIV infection. Variability in CD4+ LCs has been reported to occur as a result of measurement techniques and/or biological variations. We report on the CD4+ LCs of healthy human immunodeficiency virus (HIV)-seronegative adults in Botswana. Samples were obtained from HIV-seronegative blood donors. The median CD4+ LC was 726 cells/mm3 (for females, 782 cells/mm3; for males, 698 cells/mm3). The median CD8+ LC was 488 cells/mm 3 (for females, 494 cells/mm3; for males, 485 cells/mm3). The median CD4+-to-CD8+ ratio was 1.57 (for females, 1.66; for males, 1.51). Our findings of low CD4+ LCs among HIV-negative adults in Botswana are significant and have important implications for the management of HIV disease in the population of this sub-Saharan African country.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalClinical and Diagnostic Laboratory Immunology
Issue number5
StatePublished - Sep 1 2004
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

Cite this

Bussmann, H., Wester, C. W., Masupu, K. V., Peter, T., Gaolekwe, S. M., Kim, S., Reich, A. M., Ahn, S., Wu, Y., Thior, I., Essex, M., & Marlink, R. (2004). Low CD4+ T-lymphocyte values in human immunodeficiency virus-negative adults in Botswana. Clinical and Diagnostic Laboratory Immunology, 11(5), 930-935. https://doi.org/10.1128/CDLI.11.5.930-935.2004