Low expression of cyclin D2 in G2/M-arrested and transformed proliferating Balb/3T3 cells

Ming Zhu Fang, Moon Han Lee, Yong Soon Lee, Young Chul Kim, Byung Moo Lee, Myung Haing Cho

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

At present, the effect of cyclin D2 implicated in cell cycle regulation, differentiation, and oncogenic transformation is not fully confirmed. To better elucidate the role of cyclin D2 in controling the cell proliferation, cyclin D2 expression level was determined at the early initiation and promotion stages during the in vitro two-stage transformation process of Balb/3T3 A31 cells. N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced G2/M-arrested cells expressed low level of cyclin D2 mRNA, while the contact-inhibited nonproliferating cells expressed high level of cyclin D2 mRNA. In the transformed proliferating cells at the promotion stage, cyclin D2 mRNA was not expressed. These data suggest that cyclin D2 expression may be associated with the type of growth arrest and nonproliferating state, but not with the cell proliferation and transformation.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalJournal of Veterinary Medical Science
Volume64
Issue number3
DOIs
StatePublished - Mar 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Keywords

  • Cyclin D2
  • G2/M arrest
  • Transformation

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