Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

Jay A. Tischfield, Yu Rong Xia, Diana M. Shih, Ivana Klisak, Ju Chen, Sandra J. Engle, Aristotle N. Siakotos, Michelle V. Winstead, Jeffrey J. Seilhamer, Valérie Allamand, Gabor Gyapay, Aldons J. Lusis

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34- p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalGenomics
Volume32
Issue number3
DOIs
StatePublished - Mar 15 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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