Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

Jay A. Tischfield; Yu Rong Xia; Diana M. Shih; Ivana Klisak; Ju Chen; Sandra J. Engle; Aristotle N. Siakotos; Michelle V. Winstead; Jeffrey J. Seilhamer; Valérie Allamand; Gabor Gyapay; Aldons J. Lusis

doi:10.1006/geno.1996.0126

Low-molecular-weight, calcium-dependent phospholipase A₂ genes are linked and map to homologous chromosome regions in mouse and human

Jay A. Tischfield, Yu Rong Xia, Diana M. Shih, Ivana Klisak, Ju Chen, Sandra J. Engle, Aristotle N. Siakotos, Michelle V. Winstead, Jeffrey J. Seilhamer, Valérie Allamand, Gabor Gyapay, Aldons J. Lusis

Research output: Contribution to journal › Article › peer-review

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Abstract

The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34- p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.

Original language	English (US)
Pages (from-to)	328-333
Number of pages	6
Journal	Genomics
Volume	32
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0126
State	Published - Mar 15 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1006/geno.1996.0126

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Tischfield, J. A., Xia, Y. R., Shih, D. M., Klisak, I., Chen, J., Engle, S. J., Siakotos, A. N., Winstead, M. V., Seilhamer, J. J., Allamand, V., Gyapay, G., & Lusis, A. J. (1996). Low-molecular-weight, calcium-dependent phospholipase A₂ genes are linked and map to homologous chromosome regions in mouse and human. Genomics, 32(3), 328-333. https://doi.org/10.1006/geno.1996.0126

@article{4aa1e1f0b4b54485a7f408d58e99f23e,

title = "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human",

abstract = "The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34- p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.",

author = "Tischfield, {Jay A.} and Xia, {Yu Rong} and Shih, {Diana M.} and Ivana Klisak and Ju Chen and Engle, {Sandra J.} and Siakotos, {Aristotle N.} and Winstead, {Michelle V.} and Seilhamer, {Jeffrey J.} and Val{\'e}rie Allamand and Gabor Gyapay and Lusis, {Aldons J.}",

note = "Funding Information: We thank Prof. L. Peltonen and colleagues of The National Public Health Institute, Finland, for the gift of DNA from CLN1 patients. This work was supported in part by the Children's Brain Diseases Foundation and NIH Grants DK38185 (J.A.T.), NS30171 (A.N.S.), and HL30568 (A.J.L.).",

year = "1996",

month = mar,

day = "15",

doi = "10.1006/geno.1996.0126",

language = "English (US)",

volume = "32",

pages = "328--333",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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T1 - Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

AU - Tischfield, Jay A.

AU - Xia, Yu Rong

AU - Shih, Diana M.

AU - Klisak, Ivana

AU - Chen, Ju

AU - Engle, Sandra J.

AU - Siakotos, Aristotle N.

AU - Winstead, Michelle V.

AU - Seilhamer, Jeffrey J.

AU - Allamand, Valérie

AU - Gyapay, Gabor

AU - Lusis, Aldons J.

N1 - Funding Information: We thank Prof. L. Peltonen and colleagues of The National Public Health Institute, Finland, for the gift of DNA from CLN1 patients. This work was supported in part by the Children's Brain Diseases Foundation and NIH Grants DK38185 (J.A.T.), NS30171 (A.N.S.), and HL30568 (A.J.L.).

PY - 1996/3/15

Y1 - 1996/3/15

N2 - The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34- p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.

AB - The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34- p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.

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JO - Genomics

JF - Genomics

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ER -

Low-molecular-weight, calcium-dependent phospholipase A₂ genes are linked and map to homologous chromosome regions in mouse and human

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