Luminescent properties of water-soluble denatured bovine serum albumin-coated CdTe quantum dots

Qiang Wang, Yuching Kuo, Yuwen Wang, Gyehwa Shin, Chada Ruengruglikit, Qingrong Huang

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Chemically reduced bovine serum albumin (BSA) has been used to modify the surface of water-soluble CdTe quantum dots (QDs). It is demonstrated that the denatured BSA (dBSA) can be conjugated to the surface of CdTe QDs and thereby efficiently improve the chemical stability and the photoluminescence quantum yield (PL QY) of the QDs. It is inferred that a shell-like complex structure CdTex(dBSA)1-x will form on the surface of the CdTe "core", resulting in the enhancement of PL intensity and the blue shift of the PL peak. This study of the effects of pH and dBSA concentration on optical properties of dBSA-coated QDs suggests that, at pH 6-9, the solution of dBSA-coated CdTe QDs can keep substantial stability and fluorescent brightness, whereas further increase of pH value leads to a dramatic decrease in PL QY and chemical stability. On the other hand, too high or too low initial dBSA concentration in the QD solution results in a decrease of PL QY for dBSA-coated CdTe QDs. This study provides a new approach of preparing stable water-soluble QDs with high PL QY and controllable luminescent colors for biological labeling applications.

Original languageEnglish (US)
Pages (from-to)16860-16866
Number of pages7
JournalJournal of Physical Chemistry B
Issue number34
StatePublished - Aug 31 2006

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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