Lymphoid cell dependence of eosinophil response to antigen. V. Evidence for the induction of separate memory cells mediating cellular and humoral responses to tetanus toxoid

N. M. Ponzio, R. S. Speirs

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Spleen cells (107) derived from donors primed with tetanus toxoid 10 days previously were capable of transferring cell mediated immunity as manifested by a secondary type eosinophil response, but were not capable of adoptively transferring the capacity to mount a secondary type antitoxin response. Increasing the number of 10 day primed spleen cells transferred, or increasing the period of time between adoptive transfer and subsequent challenge did not induce measurable antitoxin titers. The data indicated that at least 2 types of memory cells were produced in response to a priming injection. The first type, which mediated the eosinophil response, was produced soon after priming and was present at 10 days in the spleen. The second type, involved in humoral antitoxin production, was not present in the spleen at 10 days, but was present 30 days after priming. It was concluded that the secondary type eosinophil response to tetanus toxoid was distinct from, and not dependent on the anamnestic antitoxin response.

Original languageEnglish (US)
Pages (from-to)405-413
Number of pages9
JournalZ.IMMUNITATSFORSCH.EXP.IMMUN.
Volume146
Issue number5
StatePublished - 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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