Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Bishuang Cai; Paola Dongiovanni; Kathleen E. Corey; Xiaobo Wang; Igor O. Shmarakov; Ze Zheng; Canan Kasikara; Viralkumar Davra; Marica Meroni; Raymond T. Chung; Carla V. Rothlin; Robert F. Schwabe; William S. Blaner; Raymond B. Birge; Luca Valenti; Ira Tabas

doi:10.1016/j.cmet.2019.11.013

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Bishuang Cai, Paola Dongiovanni, Kathleen E. Corey, Xiaobo Wang, Igor O. Shmarakov, Ze Zheng, Canan Kasikara, Viralkumar Davra, Marica Meroni, Raymond T. Chung, Carla V. Rothlin, Robert F. Schwabe, William S. Blaner, Raymond B. Birge, Luca Valenti, Ira Tabas

New Jersey Medical School (NJMS), Biochemistry

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.

Original language	English (US)
Pages (from-to)	406-421.e7
Journal	Cell Metabolism
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2019.11.013
State	Published - Feb 4 2020

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

Keywords

ADAM17
MerTK
MerTK cleavage
NASH
TGFβ;
hepatic stellate cells
liver fibrosis
macrophage
nonalcoholic steatohepatitis
retinoic acid

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10.1016/j.cmet.2019.11.013

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Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., Kasikara, C., Davra, V., Meroni, M., Chung, R. T., Rothlin, C. V., Schwabe, R. F., Blaner, W. S., Birge, R. B., Valenti, L., & Tabas, I. (2020). Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell Metabolism, 31(2), 406-421.e7. https://doi.org/10.1016/j.cmet.2019.11.013

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title = "Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis",

abstract = "Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.",

keywords = "ADAM17, MerTK, MerTK cleavage, NASH, TGFβ;, hepatic stellate cells, liver fibrosis, macrophage, nonalcoholic steatohepatitis, retinoic acid",

author = "Bishuang Cai and Paola Dongiovanni and Corey, {Kathleen E.} and Xiaobo Wang and Shmarakov, {Igor O.} and Ze Zheng and Canan Kasikara and Viralkumar Davra and Marica Meroni and Chung, {Raymond T.} and Rothlin, {Carla V.} and Schwabe, {Robert F.} and Blaner, {William S.} and Birge, {Raymond B.} and Luca Valenti and Ira Tabas",

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year = "2020",

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doi = "10.1016/j.cmet.2019.11.013",

language = "English (US)",

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T1 - Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

AU - Cai, Bishuang

AU - Dongiovanni, Paola

AU - Corey, Kathleen E.

AU - Wang, Xiaobo

AU - Shmarakov, Igor O.

AU - Zheng, Ze

AU - Kasikara, Canan

AU - Davra, Viralkumar

AU - Meroni, Marica

AU - Chung, Raymond T.

AU - Rothlin, Carla V.

AU - Schwabe, Robert F.

AU - Blaner, William S.

AU - Birge, Raymond B.

AU - Valenti, Luca

AU - Tabas, Ira

PY - 2020/2/4

Y1 - 2020/2/4

N2 - Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.

AB - Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.

KW - ADAM17

KW - MerTK

KW - MerTK cleavage

KW - NASH

KW - TGFβ;

KW - hepatic stellate cells

KW - liver fibrosis

KW - macrophage

KW - nonalcoholic steatohepatitis

KW - retinoic acid

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DO - 10.1016/j.cmet.2019.11.013

M3 - Article

C2 - 31839486

AN - SCOPUS:85078479595

SN - 1550-4131

VL - 31

SP - 406-421.e7

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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