TY - JOUR
T1 - Macrophages from unstimulated, mineral oil and thioglycollate-stimulated mice
T2 - A comparative study of surface anionic sites and phagocytosis of 'old' red blood cells
AU - Knyszynski, A.
AU - Leibovich, S. L.
AU - Skutelsky, E.
AU - Danon, D.
PY - 1978
Y1 - 1978
N2 - The authors have studied the morphology and surface negative charge of macrophages from unstimulated (UM), thioglycollate-stimulated (TM), and mineral oil-stimulated (MM) mouse peritoneal cavities, and the ability of these macrophages to recognize and phagocytize 'old' red blood cells (RBC) from syngeneic mice. Morphologic differences between the various macrophage preparations were compared by both light and electron microscopy. The UM phagocytized much more 'old' RBC than the TM and MM (UM>MM>TM). On the other hand, the surface negative charge of MM was greater than that of UM, which in turn was greater than TM (MM>UM>TM). It thus appears that no direct correlation exists between the surface negative charge of the macrophages and their ability to recognize and phagocytize 'old' RBC.
AB - The authors have studied the morphology and surface negative charge of macrophages from unstimulated (UM), thioglycollate-stimulated (TM), and mineral oil-stimulated (MM) mouse peritoneal cavities, and the ability of these macrophages to recognize and phagocytize 'old' red blood cells (RBC) from syngeneic mice. Morphologic differences between the various macrophage preparations were compared by both light and electron microscopy. The UM phagocytized much more 'old' RBC than the TM and MM (UM>MM>TM). On the other hand, the surface negative charge of MM was greater than that of UM, which in turn was greater than TM (MM>UM>TM). It thus appears that no direct correlation exists between the surface negative charge of the macrophages and their ability to recognize and phagocytize 'old' RBC.
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M3 - Article
C2 - 731628
AN - SCOPUS:0018074014
SN - 0033-6890
VL - 24
SP - 205
EP - 215
JO - RES Journal of the Reticuloendothelial Society
JF - RES Journal of the Reticuloendothelial Society
IS - 3
ER -