Magnificent seven: Roles of G protein-coupled receptors in extracellular sensing in fungi

Chaoyang Xue, Yen Ping Hsueh, Joseph Heitman

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


G protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors and are responsible for transducing extracellular signals into intracellular responses that involve complex intracellular- signaling networks. This review highlights recent research advances in fungal GPCRs, including classification, extracellular sensing, and G protein-signaling regulation. The involvement of GPCRs in pheromone and nutrient sensing has been studied extensively over the past decade. Following recent advances in fungal genome sequencing projects, a panoply of GPCR candidates has been revealed and some have been documented to play key roles sensing diverse extracellular signals, such as pheromones, sugars, amino acids, nitrogen sources, and even photons. Identification and deorphanization of additional putative GPCRs may require the development of new research tools. Here, we compare research on GPCRs in fungi with information derived from mammalian systems to provide a useful road map on how to better understand ligand-GPCR-G protein interactions in general. We also emphasize the utility of yeast as a discovery tool for systemic studies of GPCRs from other organisms.

Original languageEnglish (US)
Pages (from-to)1010-1032
Number of pages23
JournalFEMS Microbiology Reviews
Issue number6
StatePublished - Nov 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases


  • Extracellular sensing
  • Fungus
  • G protein
  • G protein-coupled receptor


Dive into the research topics of 'Magnificent seven: Roles of G protein-coupled receptors in extracellular sensing in fungi'. Together they form a unique fingerprint.

Cite this