Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

Derek B. Sant'Angelo, Peter Cresswell, Charles A. Janeway, Lisa K. Denzin

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic exclusion has been shown to be leaky for the β chain and, more commonly, for the α chain. Here, we demonstrate an additional mechanism by which T cells can maintain monoclonality. T cells from double TCR transgenic mice express only one or the other of the two available TCRs at the cell surface. This "functional allelic exclusion" is apparently due to control of the TCR assembly process because these T cells express RNA and protein for all four transgenic TCR proteins. Lack of cell surface expression of the second TCR may be controlled by a failure to assemble the TCR heterodimer.

Original languageEnglish (US)
Pages (from-to)6824-6829
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number12
StatePublished - Jun 5 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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