Making concentrated pterostilbene highly bioavailable in pressure processed phospholipid nanoemulsion

Fu Min Sun, Yu Jou Chou, Qingrong Huang, Jing Yu Hu, Yuwen Ting

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Pterostilbene, a dimethylether analog of resveratrol, has been found to have potent biological activity. However, the bioavailability of pterostilbene in the biological system is limited due to its poor solubility in an aqueous environment. A nanoemulsion system was designed for this purpose. Lecithin-based nanoemulsion was formed after 3 cycles through a high-pressure homogenizer at 500 psi. The rheological properties and particle size were measured using dynamic light scattering and a viscometer. The storage stabilities of the prepared formulation were determined based on its ability to maintain its particle size and loading concentration. According to the experimental results, the lecithin-based nanoemulsion system contained approximately 9.5% of pterostilbene. Over the 28-day stability test, the particle size, zeta potential, and encapsulation of pterostilbene in the nanoemulsion did not change significantly, indicating good storage stability. The positive effect of the prepared nanoemulsion system on bioavailability was studied and confirmed using in vitro lipolysis and a caco-2 monolayer model.

Original languageEnglish (US)
Article number294
Pages (from-to)1-15
Number of pages15
Issue number2
StatePublished - Feb 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology


  • Bioavailability
  • Encapsulation
  • Lecithin
  • Nanoemulsion
  • Pterostilbene


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