Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

Nadia Jaber, Zhixun Dou, Richard Z. Lin, Jianhua Zhang, Wei Xing Zong

Research output: Contribution to journalShort survey

17 Scopus citations

Abstract

PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.

Original languageEnglish (US)
Pages (from-to)707-708
Number of pages2
JournalAutophagy
Volume8
Issue number4
DOIs
StatePublished - Apr 2012

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • Autophagy
  • Cancer
  • Endocytosis
  • Heart
  • Liver
  • PIK3C3
  • PtdIns3K
  • PtdIns3P
  • VPS34

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