Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

Nadia Jaber; Zhixun Dou; Richard Z. Lin; Jianhua Zhang; Wei Xing Zong

doi:10.4161/auto.19627

Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

Nadia Jaber, Zhixun Dou, Richard Z. Lin, Jianhua Zhang, Wei Xing Zong

Research output: Contribution to journal › Short survey › peer-review

22 Scopus citations

Abstract

PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.

Original language	English (US)
Pages (from-to)	707-708
Number of pages	2
Journal	Autophagy
Volume	8
Issue number	4
DOIs	https://doi.org/10.4161/auto.19627
State	Published - Apr 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Keywords

Autophagy
Cancer
Endocytosis
Heart
Liver
PIK3C3
PtdIns3K
PtdIns3P
VPS34

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10.4161/auto.19627

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title = "Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart",

abstract = "PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.",

keywords = "Autophagy, Cancer, Endocytosis, Heart, Liver, PIK3C3, PtdIns3K, PtdIns3P, VPS34",

author = "Nadia Jaber and Zhixun Dou and Lin, {Richard Z.} and Jianhua Zhang and Zong, {Wei Xing}",

year = "2012",

month = apr,

doi = "10.4161/auto.19627",

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volume = "8",

pages = "707--708",

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T1 - Mammalian PIK3C3/VPS34

T2 - The key to autophagic processing in liver and heart

AU - Jaber, Nadia

AU - Dou, Zhixun

AU - Lin, Richard Z.

AU - Zhang, Jianhua

AU - Zong, Wei Xing

PY - 2012/4

Y1 - 2012/4

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AB - PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.

KW - Autophagy

KW - Cancer

KW - Endocytosis

KW - Heart

KW - Liver

KW - PIK3C3

KW - PtdIns3K

KW - PtdIns3P

KW - VPS34

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DO - 10.4161/auto.19627

M3 - Short survey

C2 - 22498475

AN - SCOPUS:84862283776

SN - 1554-8627

VL - 8

SP - 707

EP - 708

JO - Autophagy

JF - Autophagy

IS - 4

ER -

Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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