Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A. Rüegg, Alan Hall, Michael N. Hall

Research output: Contribution to journalArticlepeer-review

1520 Scopus citations

Abstract

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein complexes: TORC1 and TORC2. A mammalian counterpart of TORC1 (mTORC1) has been described, but it is not known whether TORC2 is conserved in mammals. Here, we report that a mammalian counterpart of TORC2 (mTORC2) also exists. mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor. Like yeast TORC2, mTORC2 is rapamycin insensitive and seems to function upstream of Rho GTPases to regulate the actin cytoskeleton. mTORC2 is not upstream of the mTORC1 effector S6K. Thus, two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.

Original languageEnglish (US)
Pages (from-to)1122-1128
Number of pages7
JournalNature Cell Biology
Volume6
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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