Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels; Avraham Eisbruch; Jonathan J. Beitler; June Corry; Carol R. Bradford; Nabil F. Saba; Michiel W.M. van den Brekel; Robert Smee; Primož Strojan; Carlos Suárez; William M. Mendenhall; Robert P. Takes; Juan P. Rodrigo; Missak Haigentz; Alexander D. Rapidis; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s00405-015-3771-x

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels, Avraham Eisbruch, Jonathan J. Beitler, June Corry, Carol R. Bradford, Nabil F. Saba, Michiel W.M. van den Brekel, Robert Smee, Primož Strojan, Carlos Suárez, William M. Mendenhall, Robert P. Takes, Juan P. Rodrigo, Missak Haigentz, Alexander D. Rapidis, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

Original language	English (US)
Pages (from-to)	2877-2894
Number of pages	18
Journal	European Archives of Oto-Rhino-Laryngology
Volume	273
Issue number	10
DOIs	https://doi.org/10.1007/s00405-015-3771-x
State	Published - Oct 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

Keywords

Cetuximab
EGFR
HPV
Hypoxia
Oropharyngeal carcinoma
p16
Radiosensitivity
TORS
Treatment de-intensification

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10.1007/s00405-015-3771-x

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Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., van den Brekel, M. W. M., Smee, R., Strojan, P., Suárez, C., Mendenhall, W. M., Takes, R. P., Rodrigo, J. P., Haigentz, M., Rapidis, A. D., Rinaldo, A., & Ferlito, A. (2016). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we? European Archives of Oto-Rhino-Laryngology, 273(10), 2877-2894. https://doi.org/10.1007/s00405-015-3771-x

@article{8d37e895437c4865af1fb3e576adecca,

title = "Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?",

abstract = "HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.",

keywords = "Cetuximab, EGFR, HPV, Hypoxia, Oropharyngeal carcinoma, p16, Radiosensitivity, TORS, Treatment de-intensification",

author = "Samuels, {Stuart E.} and Avraham Eisbruch and Beitler, {Jonathan J.} and June Corry and Bradford, {Carol R.} and Saba, {Nabil F.} and {van den Brekel}, {Michiel W.M.} and Robert Smee and Primo{\v z} Strojan and Carlos Su{\'a}rez and Mendenhall, {William M.} and Takes, {Robert P.} and Rodrigo, {Juan P.} and Missak Haigentz and Rapidis, {Alexander D.} and Alessandra Rinaldo and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",

year = "2016",

month = oct,

day = "1",

doi = "10.1007/s00405-015-3771-x",

language = "English (US)",

volume = "273",

pages = "2877--2894",

journal = "European Archives of Oto-Rhino-Laryngology",

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Samuels, SE, Eisbruch, A, Beitler, JJ, Corry, J, Bradford, CR, Saba, NF, van den Brekel, MWM, Smee, R, Strojan, P, Suárez, C, Mendenhall, WM, Takes, RP, Rodrigo, JP, Haigentz, M, Rapidis, AD, Rinaldo, A & Ferlito, A 2016, 'Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?', European Archives of Oto-Rhino-Laryngology, vol. 273, no. 10, pp. 2877-2894. https://doi.org/10.1007/s00405-015-3771-x

TY - JOUR

T1 - Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma

T2 - where are we?

AU - Samuels, Stuart E.

AU - Eisbruch, Avraham

AU - Beitler, Jonathan J.

AU - Corry, June

AU - Bradford, Carol R.

AU - Saba, Nabil F.

AU - van den Brekel, Michiel W.M.

AU - Smee, Robert

AU - Strojan, Primož

AU - Suárez, Carlos

AU - Mendenhall, William M.

AU - Takes, Robert P.

AU - Rodrigo, Juan P.

AU - Haigentz, Missak

AU - Rapidis, Alexander D.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2016/10/1

Y1 - 2016/10/1

N2 - HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

AB - HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

KW - Cetuximab

KW - EGFR

KW - HPV

KW - Hypoxia

KW - Oropharyngeal carcinoma

KW - p16

KW - Radiosensitivity

KW - TORS

KW - Treatment de-intensification

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AN - SCOPUS:84944556321

SN - 0937-4477

VL - 273

SP - 2877

EP - 2894

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

IS - 10

ER -

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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