Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Mihael H. Polymeropoulos; Joseph J. Higgins; Lawrence I. Golbe; William G. Johnson; Susan E. Ide; Giuseppe Di Iorio; Giuseppe Sanges; Edward S. Stenroos; Lana T. Pho; Alejandro A. Schaffer; Alice M. Lazzarini; Robert L. Nussbaum; Roger C. Duvoisin

doi:10.1126/science.274.5290.1197

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Mihael H. Polymeropoulos, Joseph J. Higgins, Lawrence I. Golbe, William G. Johnson, Susan E. Ide, Giuseppe Di Iorio, Giuseppe Sanges, Edward S. Stenroos, Lana T. Pho, Alejandro A. Schaffer, Alice M. Lazzarini, Robert L. Nussbaum, Roger C. Duvoisin

Research output: Contribution to journal › Article › peer-review

598 Scopus citations

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately I percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

Original language	English (US)
Pages (from-to)	1197-1199
Number of pages	3
Journal	Science
Volume	274
Issue number	5290
DOIs	https://doi.org/10.1126/science.274.5290.1197
State	Published - Nov 15 1996

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1126/science.274.5290.1197

Cite this

@article{5d241c30a9a34890aea9ac4147588470,

title = "Mapping of a gene for Parkinson's disease to chromosome 4q21-q23",

abstract = "Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately I percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.",

author = "Polymeropoulos, {Mihael H.} and Higgins, {Joseph J.} and Golbe, {Lawrence I.} and Johnson, {William G.} and Ide, {Susan E.} and {Di Iorio}, Giuseppe and Giuseppe Sanges and Stenroos, {Edward S.} and Pho, {Lana T.} and Schaffer, {Alejandro A.} and Lazzarini, {Alice M.} and Nussbaum, {Robert L.} and Duvoisin, {Roger C.}",

year = "1996",

month = nov,

day = "15",

doi = "10.1126/science.274.5290.1197",

language = "English (US)",

volume = "274",

pages = "1197--1199",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5290",

}

TY - JOUR

T1 - Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

AU - Polymeropoulos, Mihael H.

AU - Higgins, Joseph J.

AU - Golbe, Lawrence I.

AU - Johnson, William G.

AU - Ide, Susan E.

AU - Di Iorio, Giuseppe

AU - Sanges, Giuseppe

AU - Stenroos, Edward S.

AU - Pho, Lana T.

AU - Schaffer, Alejandro A.

AU - Lazzarini, Alice M.

AU - Nussbaum, Robert L.

AU - Duvoisin, Roger C.

PY - 1996/11/15

Y1 - 1996/11/15

N2 - Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately I percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

AB - Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately I percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

UR - http://www.scopus.com/inward/record.url?scp=10544234193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10544234193&partnerID=8YFLogxK

U2 - 10.1126/science.274.5290.1197

DO - 10.1126/science.274.5290.1197

M3 - Article

C2 - 8895469

AN - SCOPUS:10544234193

VL - 274

SP - 1197

EP - 1199

JO - Science

JF - Science

SN - 0036-8075

IS - 5290

ER -

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this