Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Mihael H. Polymeropoulos, Joseph J. Higgins, Lawrence I. Golbe, William G. Johnson, Susan E. Ide, Giuseppe Di Iorio, Giuseppe Sanges, Edward S. Stenroos, Lana T. Pho, Alejandro A. Schaffer, Alice M. Lazzarini, Robert L. Nussbaum, Roger C. Duvoisin

Research output: Contribution to journalArticlepeer-review

598 Scopus citations

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately I percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)1197-1199
Number of pages3
JournalScience
Volume274
Issue number5290
DOIs
StatePublished - Nov 15 1996

All Science Journal Classification (ASJC) codes

  • General

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