Mass spectrometry in organic and bio-organic catalysis: Using thermochemical properties to lend insight into mechanism

Damon J. Hinz; Lanxin Zhang; Jeehiun K. Lee

doi:10.1002/mas.21797

Mass spectrometry in organic and bio-organic catalysis: Using thermochemical properties to lend insight into mechanism

Damon J. Hinz, Lanxin Zhang, Jeehiun K. Lee

School of Arts and Sciences, Chemistry & Chemical Biology

Research output: Contribution to journal › Article › peer-review

Abstract

In this review, we discuss gas phase experimentation centered on the measurement of acidity and proton affinity of substrates that are useful for understanding catalytic mechanisms. The review is divided into two parts. The first covers examples of organocatalysis, while the second focuses on biological catalysis. The utility of gas phase acidity and basicity values for lending insight into mechanisms of catalysis is highlighted.

Original language	English (US)
Pages (from-to)	1965-1983
Number of pages	19
Journal	Mass Spectrometry Reviews
Volume	42
Issue number	5
DOIs	https://doi.org/10.1002/mas.21797
State	Published - Sep 1 2023

All Science Journal Classification (ASJC) codes

Condensed Matter Physics
Analytical Chemistry
General Biochemistry, Genetics and Molecular Biology
Spectroscopy

Keywords

acidity
enzymes
organocatalysts
proton affinity
reaction mechanisms

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10.1002/mas.21797

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KW - enzymes

KW - organocatalysts

KW - proton affinity

KW - reaction mechanisms

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Mass spectrometry in organic and bio-organic catalysis: Using thermochemical properties to lend insight into mechanism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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