Massage therapy for osteoarthritis of the knee: A randomized dose-finding trial

Adam I. Perlman, Ather Ali, Valentine Yanchou Njike, David Hom, Anna Davidi, Susan Gould-Fogerite, Carl Milak, David L. Katz

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: In a previous trial of massage for osteoarthritis (OA) of the knee, we demonstrated feasibility, safety and possible efficacy, with benefits that persisted at least 8 weeks beyond treatment termination. Methods: We performed a RCT to identify the optimal dose of massage within an 8-week treatment regimen and to further examine durability of response. Participants were 125 adults with OA of the knee, randomized to one of four 8-week regimens of a standardized Swedish massage regimen (30 or 60 min weekly or biweekly) or to a Usual Care control. Outcomes included the Western Ontario and McMaster Universities Arthritis Index (WOMAC), visual analog pain scale, range of motion, and time to walk 50 feet, assessed at baseline, 8-, 16-, and 24-weeks. Results: WOMAC Global scores improved significantly (24.0 points, 95% CI ranged from 15.3-32.7) in the 60-minute massage groups compared to Usual Care (6.3 points, 95% CI 0.1-12.8) at the primary endpoint of 8-weeks. WOMAC subscales of pain and functionality, as well as the visual analog pain scale also demonstrated significant improvements in the 60-minute doses compared to usual care. No significant differences were seen in range of motion at 8-weeks, and no significant effects were seen in any outcome measure at 24-weeks compared to usual care. A dose-response curve based on WOMAC Global scores shows increasing effect with greater total time of massage, but with a plateau at the 60-minute/week dose. Conclusion: Given the superior convenience of a once-weekly protocol, cost savings, and consistency with a typical real-world massage protocol, the 60-minute once weekly dose was determined to be optimal, establishing a standard for future trials. Trial Registration: ClinicalTrials.gov NCT00970008.

Original languageEnglish (US)
Article numbere30248
JournalPloS one
Volume7
Issue number2
DOIs
StatePublished - Feb 8 2012

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massage
Massage
Knee Osteoarthritis
osteoarthritis
knees
Durability
therapeutics
dosage
Costs
Pain Measurement
Articular Range of Motion
Point-of-Care Systems
Cost Savings
arthritis
cost effectiveness
Ontario
durability
endpoints
Arthritis
dose response

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Perlman, A. I., Ali, A., Njike, V. Y., Hom, D., Davidi, A., Gould-Fogerite, S., ... Katz, D. L. (2012). Massage therapy for osteoarthritis of the knee: A randomized dose-finding trial. PloS one, 7(2), [e30248]. https://doi.org/10.1371/journal.pone.0030248
Perlman, Adam I. ; Ali, Ather ; Njike, Valentine Yanchou ; Hom, David ; Davidi, Anna ; Gould-Fogerite, Susan ; Milak, Carl ; Katz, David L. / Massage therapy for osteoarthritis of the knee : A randomized dose-finding trial. In: PloS one. 2012 ; Vol. 7, No. 2.
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Perlman, AI, Ali, A, Njike, VY, Hom, D, Davidi, A, Gould-Fogerite, S, Milak, C & Katz, DL 2012, 'Massage therapy for osteoarthritis of the knee: A randomized dose-finding trial', PloS one, vol. 7, no. 2, e30248. https://doi.org/10.1371/journal.pone.0030248

Massage therapy for osteoarthritis of the knee : A randomized dose-finding trial. / Perlman, Adam I.; Ali, Ather; Njike, Valentine Yanchou; Hom, David; Davidi, Anna; Gould-Fogerite, Susan; Milak, Carl; Katz, David L.

In: PloS one, Vol. 7, No. 2, e30248, 08.02.2012.

Research output: Contribution to journalArticle

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T1 - Massage therapy for osteoarthritis of the knee

T2 - A randomized dose-finding trial

AU - Perlman, Adam I.

AU - Ali, Ather

AU - Njike, Valentine Yanchou

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AU - Gould-Fogerite, Susan

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AU - Katz, David L.

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