Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex

William Johnson, Steven Buyske, Edward S. Stenroos, George H. Lambert

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.

Original languageEnglish (US)
Title of host publicationMaternal Influences on Fetal Neurodevelopment
Subtitle of host publicationClinical and Research Aspects
PublisherSpringer New York
Pages137-160
Number of pages24
ISBN (Print)9781603279208
DOIs
StatePublished - Dec 1 2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Autism
  • Developmental genes
  • Maternal
  • Maternal effects
  • Maternally acting gene alleles
  • Pregnancy
  • Teratogenesis

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    Johnson, W., Buyske, S., Stenroos, E. S., & Lambert, G. H. (2010). Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex. In Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects (pp. 137-160). Springer New York. https://doi.org/10.1007/978-1-60327-921-5_9