Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex

William Johnson, Steven Buyske, Edward S. Stenroos, George H. Lambert

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.

Original languageEnglish (US)
Title of host publicationMaternal Influences on Fetal Neurodevelopment
Subtitle of host publicationClinical and Research Aspects
PublisherSpringer New York
Pages137-160
Number of pages24
ISBN (Print)9781603279208
DOIs
StatePublished - Dec 1 2010

Fingerprint

HLA-DR4 Antigen
Autistic Disorder
Major Histocompatibility Complex
Alleles
Genes
Mothers
Phenotype
Pregnancy
Neurodevelopmental Disorders

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Autism
  • Developmental genes
  • Maternal
  • Maternal effects
  • Maternally acting gene alleles
  • Pregnancy
  • Teratogenesis

Cite this

Johnson, W., Buyske, S., Stenroos, E. S., & Lambert, G. H. (2010). Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex. In Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects (pp. 137-160). Springer New York. https://doi.org/10.1007/978-1-60327-921-5_9
Johnson, William ; Buyske, Steven ; Stenroos, Edward S. ; Lambert, George H. / Maternally acting alleles in autism and other neurodevelopmental disorders : The role of HLA-DR4 within the major histocompatibility complex. Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects. Springer New York, 2010. pp. 137-160
@inbook{c12beea1f36347339cbc34df26ed5844,
title = "Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex",
abstract = "Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.",
keywords = "Autism, Developmental genes, Maternal, Maternal effects, Maternally acting gene alleles, Pregnancy, Teratogenesis",
author = "William Johnson and Steven Buyske and Stenroos, {Edward S.} and Lambert, {George H.}",
year = "2010",
month = "12",
day = "1",
doi = "10.1007/978-1-60327-921-5_9",
language = "English (US)",
isbn = "9781603279208",
pages = "137--160",
booktitle = "Maternal Influences on Fetal Neurodevelopment",
publisher = "Springer New York",
address = "United States",

}

Johnson, W, Buyske, S, Stenroos, ES & Lambert, GH 2010, Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex. in Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects. Springer New York, pp. 137-160. https://doi.org/10.1007/978-1-60327-921-5_9

Maternally acting alleles in autism and other neurodevelopmental disorders : The role of HLA-DR4 within the major histocompatibility complex. / Johnson, William; Buyske, Steven; Stenroos, Edward S.; Lambert, George H.

Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects. Springer New York, 2010. p. 137-160.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Maternally acting alleles in autism and other neurodevelopmental disorders

T2 - The role of HLA-DR4 within the major histocompatibility complex

AU - Johnson, William

AU - Buyske, Steven

AU - Stenroos, Edward S.

AU - Lambert, George H.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.

AB - Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.

KW - Autism

KW - Developmental genes

KW - Maternal

KW - Maternal effects

KW - Maternally acting gene alleles

KW - Pregnancy

KW - Teratogenesis

UR - http://www.scopus.com/inward/record.url?scp=84889984133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889984133&partnerID=8YFLogxK

U2 - 10.1007/978-1-60327-921-5_9

DO - 10.1007/978-1-60327-921-5_9

M3 - Chapter

AN - SCOPUS:84889984133

SN - 9781603279208

SP - 137

EP - 160

BT - Maternal Influences on Fetal Neurodevelopment

PB - Springer New York

ER -

Johnson W, Buyske S, Stenroos ES, Lambert GH. Maternally acting alleles in autism and other neurodevelopmental disorders: The role of HLA-DR4 within the major histocompatibility complex. In Maternal Influences on Fetal Neurodevelopment: Clinical and Research Aspects. Springer New York. 2010. p. 137-160 https://doi.org/10.1007/978-1-60327-921-5_9