Mathematical modeling of the co-recessive inheritance model linking molecular events to Baysian epidemiologic analysis of cancer-prone conditions in the general population

W. Clark Lambert, Muriel W. Lambert

Research output: Contribution to journalConference articlepeer-review

Abstract

Combining combinatoric analysis with the Hardy-Weinberg law of genetics, it is shown that in corecessive inheritance a small number of extremely common genes could account for a much larger number of genetic subtypes (complementation groups), each one occurring in very low frequency. This analysis is developed further, and it is shown that combining Baysian analysis of these rare disorders with the Weinberg-Dahlberg equation of population genetics leads to some unexpected conclusions regarding the occurrence of disorders transmitted by corecessive inheritance in families and the tendency or lack of it for the parents of those patients to be consanguineous.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume11 pt 1
StatePublished - Nov 1989
EventImages of the Twenty-First Century - Proceedings of the 11th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 - Seattle, WA, USA
Duration: Nov 9 1989Nov 12 1989

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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