Matrix independent label-free nanoelectronic biosensor

Rahim Esfandyarpour, Mehdi Javanmard, Zahra Koochak, James S. Harris, Ronald W. Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Previously we presented a novel, label free and real time electrical impedance biosensor, referred to as the nanoneedle biosensor. The nanoneedle is an ultrasensitive and localized device, which has the ability to directly measure biomolecular binding as a function of time. Label-free electronic sensors generally operate in low salt-concentration buffers [1] making them impractical for analyzing complex biological mixtures, which have salt concentrations as high as several hundred millimolar. In this study we have demonstrated detection of a clinically relevant cancer biomarker suspended in high salt buffer (> 100mM) with a detection limit of 2 ng/ml.

Original languageEnglish (US)
Title of host publicationMEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1083-1086
Number of pages4
ISBN (Print)9781479935086
DOIs
StatePublished - 2014
Externally publishedYes
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: Jan 26 2014Jan 30 2014

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/26/141/30/14

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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