Measuring the hydrophobicity of lubricated blends of pharmaceutical excipients

Marcos Llusa, Michael Levin, Ronald D. Snee, Fernando Muzzio

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This paper discusses how the hydrophobicity of lubricated pharmaceutical formulations is affected by process variables such as shear rate and strain. Hydrophobicity is a critical property that affects the dissolution of powder formulations, tablets and capsules as well as the performance of tablet coating and granulation operations. In this paper, hydrophobicity is measured using a modified Washburn method. Results show that, in the absence of lubricant, the hydrophobicity of powders does not change substantially as a function of shear rate or strain. However, when magnesium stearate is present (concentrations studied here range between 0.5% and 2%), hydrophobicity increases as a function of strain, shear rate and lubricant concentration. Observed changes range over several orders of magnitude, readily explaining common "overlubrication" observations of delayed drug dissolution.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalPowder Technology
Volume198
Issue number1
DOIs
StatePublished - Feb 20 2010

Fingerprint

Excipients
Hydrophobicity
Drug products
Shear deformation
Pharmaceutical Preparations
Shear strain
Powders
Tablets
Lubricants
Dissolution
Granulation
Capsules
Magnesium
Coatings

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Keywords

  • Dissolution
  • Lubrication
  • Magnesium stearate
  • Wettability

Cite this

Llusa, Marcos ; Levin, Michael ; Snee, Ronald D. ; Muzzio, Fernando. / Measuring the hydrophobicity of lubricated blends of pharmaceutical excipients. In: Powder Technology. 2010 ; Vol. 198, No. 1. pp. 101-107.
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Measuring the hydrophobicity of lubricated blends of pharmaceutical excipients. / Llusa, Marcos; Levin, Michael; Snee, Ronald D.; Muzzio, Fernando.

In: Powder Technology, Vol. 198, No. 1, 20.02.2010, p. 101-107.

Research output: Contribution to journalArticle

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AU - Levin, Michael

AU - Snee, Ronald D.

AU - Muzzio, Fernando

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AB - This paper discusses how the hydrophobicity of lubricated pharmaceutical formulations is affected by process variables such as shear rate and strain. Hydrophobicity is a critical property that affects the dissolution of powder formulations, tablets and capsules as well as the performance of tablet coating and granulation operations. In this paper, hydrophobicity is measured using a modified Washburn method. Results show that, in the absence of lubricant, the hydrophobicity of powders does not change substantially as a function of shear rate or strain. However, when magnesium stearate is present (concentrations studied here range between 0.5% and 2%), hydrophobicity increases as a function of strain, shear rate and lubricant concentration. Observed changes range over several orders of magnitude, readily explaining common "overlubrication" observations of delayed drug dissolution.

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