mecA-blaZ corepressors in clinical Staphylococcus aureus isolates

Adriana E. Rosato; Barry N. Kreiswirth; William A. Craig; William Eisner; Michael W. Climo; Gordon L. Archer

doi:10.1128/AAC.47.4.1460-1463.2003

mecA-blaZ corepressors in clinical Staphylococcus aureus isolates

Adriana E. Rosato, Barry N. Kreiswirth, William A. Craig, William Eisner, Michael W. Climo, Gordon L. Archer

New Jersey Medical School (NJMS), Public Health Research Institute Center

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

Original language	English (US)
Pages (from-to)	1460-1463
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	47
Issue number	4
DOIs	https://doi.org/10.1128/AAC.47.4.1460-1463.2003
State	Published - Apr 1 2003

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.47.4.1460-1463.2003

Cite this

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abstract = "The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.",

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T1 - mecA-blaZ corepressors in clinical Staphylococcus aureus isolates

AU - Rosato, Adriana E.

AU - Kreiswirth, Barry N.

AU - Craig, William A.

AU - Eisner, William

AU - Climo, Michael W.

AU - Archer, Gordon L.

PY - 2003/4/1

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AB - The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

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mecA-blaZ corepressors in clinical Staphylococcus aureus isolates

Abstract

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