Mechanical control of growth: Ideas, facts and challenges

Kenneth Irvine, Boris I. Shraiman

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

In his classic book On Growth and Form, D’Arcy Thompson discussed the necessity of a physical and mathematical approach to understanding the relationship between growth and form. The past century has seen extraordinary advances in our understanding of biological components and processes contributing to organismal morphogenesis, but the mathematical and physical principles involved have not received comparable attention. The most obvious entry of physics into morphogenesis is via tissue mechanics. In this Review, we discuss the fundamental role of mechanical interactions between cells induced by growth in shaping a tissue. Non-uniform growth can lead to accumulation of mechanical stress, which in the context of two-dimensional sheets of tissue can specify the shape it assumes in three dimensions. A special class of growth patterns conformal growth – does not lead to the accumulation of stress and can generate a rich variety of planar tissue shapes. Conversely, mechanical stress can provide a regulatory feedback signal into the growth control circuit. Both theory and experiment support a key role for mechanical interactions in shaping tissues and, via mechanical feedback, controlling epithelial growth.

Original languageEnglish (US)
Pages (from-to)4238-4248
Number of pages11
JournalDevelopment (Cambridge)
Volume144
Issue number23
DOIs
StatePublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Growth
  • Hippo
  • Mechanics
  • Stress

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