Mechanical enhancement of a tissue-engineered scaffold for bone regeneration

Pushpendra Patel, Brittany Taylor, Joseph Freeman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

With over 600,000 patients suffering from bone deficiencies annually in the United States, bone regeneration has come to the forefront of medical research. Current repair treatments utilize autografts (transplanting a patient's own bone from one site to another) and allografts (tissue donated from a cadaver) to treat extensive bone fractures. Although the autograft is the benchmark treatment, both autografts and allografts have their drawbacks such as donor site morbidity and disease transmission, respectively. As a result, alternative treatment methods including tissue-engineered solutions are being explored to potentially circumvent these disadvantages. The Musculoskeletal Tissue Regeneration laboratory has previously created a composite trabecular and cortical biomimetic synthetic bone scaffold, which mimics the architecture of native bone. However, the compressive strength of the current cortical scaffold does not match that of native bone. This study specifically focuses on the incorporation of sintered hydroxyapatite (HAP) columns to enhance the mechanical properties of these scaffolds, particularly under compressive loads. The integration of mechanically enhanced HAP columns serves as a promising step towards developing one of the first biomimetic bone scaffolds that exhibits the mechanical properties of native bone, while simultaneously promoting osteoblastic and vascular differentiation.

Original languageEnglish (US)
Title of host publicationProceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479937288
DOIs
StatePublished - Dec 2 2014
Event2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 - Boston, United States
Duration: Apr 25 2014Apr 27 2014

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Volume2014-December
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Other

Other2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
CountryUnited States
CityBoston
Period4/25/144/27/14

All Science Journal Classification (ASJC) codes

  • Bioengineering

Keywords

  • bone regeneration
  • hydroxyapatite
  • load-bearing scaffold

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  • Cite this

    Patel, P., Taylor, B., & Freeman, J. (2014). Mechanical enhancement of a tissue-engineered scaffold for bone regeneration. In Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 [6972901] (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; Vol. 2014-December). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2014.6972901