Mechanism of Brønsted Acid-Catalyzed Glucose Dehydration

Liu Yang, Georgios Tsilomelekis, Stavros Caratzoulas, Dionisios G. Vlachos

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We present the first DFT-based microkinetic model for the Brønsted acid-catalyzed conversion of glucose to 5-hydroxylmethylfurfural (HMF), levulinic acid (LA), and formic acid (FA) and perform kinetic and isotopic tracing NMR spectroscopy mainly at low conversions. We reveal that glucose dehydrates through a cyclic path. Our modeling results are in excellent agreement with kinetic data and indicate that the rate-limiting step is the first dehydration of protonated glucose and that the majority of glucose is consumed through the HMF intermediate. We introduce a combination of 1) automatic mechanism generation with isotopic tracing experiments and 2) elementary reaction flux analysis of important paths with NMR spectroscopy and kinetic experiments to assess mechanisms. We find that the excess formic acid, which appears at high temperatures and glucose conversions, originates from retro-aldol chemistry that involves the C6 carbon atom of glucose.

Original languageEnglish (US)
Pages (from-to)1334-1341
Number of pages8
JournalChemSusChem
Volume8
Issue number8
DOIs
StatePublished - Apr 24 2015
Externally publishedYes

Fingerprint

Dehydration
dehydration
Glucose
glucose
formic acid
Acids
acid
Formic acid
kinetics
Nuclear magnetic resonance spectroscopy
Kinetics
nuclear magnetic resonance
spectroscopy
Discrete Fourier transforms
Carbon
experiment
Experiments
Fluxes
Atoms
carbon

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Chemical Engineering(all)
  • Materials Science(all)
  • Energy(all)

Cite this

Yang, Liu ; Tsilomelekis, Georgios ; Caratzoulas, Stavros ; Vlachos, Dionisios G. / Mechanism of Brønsted Acid-Catalyzed Glucose Dehydration. In: ChemSusChem. 2015 ; Vol. 8, No. 8. pp. 1334-1341.
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Mechanism of Brønsted Acid-Catalyzed Glucose Dehydration. / Yang, Liu; Tsilomelekis, Georgios; Caratzoulas, Stavros; Vlachos, Dionisios G.

In: ChemSusChem, Vol. 8, No. 8, 24.04.2015, p. 1334-1341.

Research output: Contribution to journalArticle

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