Mechanism of fluoroquinolone action

Research output: Contribution to journalReview articlepeer-review

236 Scopus citations

Abstract

When fluoroquinolones bind to gyrase or topoisomerase IV in the presence of DNA, they alter protein conformation. DNA cleavage results with diminished religation, so the enzymes are trapped in ternary complexes with drug and cleaved DNA. Preferential localization of gyrase ahead of replication forks and topoisomerase IV behind them causes fluoroquinolone-mediated complexes with the two enzymes to have different physiological consequences.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalCurrent Opinion in Microbiology
Volume2
Issue number5
DOIs
StatePublished - Oct 1 1999

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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