Mechanism of immunosuppression in leprosy- macrophage membrane alterations

P. R. Salgame; T. J. Birdi; S. J. Lad; P. R. Mahadevan; N. H. Antia

Mechanism of immunosuppression in leprosy- macrophage membrane alterations

P. R. Salgame, T. J. Birdi, S. J. Lad, P. R. Mahadevan, N. H. Antia

Research output: Contribution to journal › Article › peer-review

Abstract

L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.

Original language	English (US)
Pages (from-to)	145-149
Number of pages	5
Journal	Journal of Clinical and Laboratory Immunology
Volume	14
Issue number	3
State	Published - 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology

Cite this

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title = "Mechanism of immunosuppression in leprosy- macrophage membrane alterations",

abstract = "L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.",

author = "Salgame, {P. R.} and Birdi, {T. J.} and Lad, {S. J.} and Mahadevan, {P. R.} and Antia, {N. H.}",

year = "1984",

language = "English (US)",

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journal = "Journal of Clinical and Laboratory Immunology",

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AU - Salgame, P. R.

AU - Birdi, T. J.

AU - Lad, S. J.

AU - Mahadevan, P. R.

AU - Antia, N. H.

PY - 1984

Y1 - 1984

N2 - L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.

AB - L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.

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AN - SCOPUS:0021265950

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IS - 3

ER -

Mechanism of immunosuppression in leprosy- macrophage membrane alterations

Abstract

All Science Journal Classification (ASJC) codes

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