Mechanism of macrophage reversal of friend erythroleukemia: Macrophage regulation of normal and leukemic erythropoiesis1

Candace S. Johnson, Sally M. Thurlow, John F. Marcelletti, Philip Furmanski

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The acute erythroleukemia induced in mice by the anemia-inducing strain of the Friend virus complex is caused to regress by normal macrophages. We examined the possibility that reversal of leukemia is related to a macrophage regulatory function in erythropoiesis. We found that the ability of macrophages to induce leukemia regression correlates with nonimmunological in vivo suppression of normal and susceptible leukemic erythroid progenitors. The macrophage effect on erythropoiesis appears to be due to changes in a humoral regulator, related to but independent of erythropoietin. The results suggest a novel regulatory system for erythropoiesis, operative in vivo, and involving macrophages as accessory or suppressor cells. This regulation appears to be disrupted in erythroleukemic mice, but can be restored, and the disease can be made to regress by treatment with normal macrophages.

Original languageEnglish (US)
Pages (from-to)3896-3902
Number of pages7
JournalCancer Research
Volume46
Issue number8
StatePublished - Aug 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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