Mechanism of the superoxide scavenging activity of neoandrographolide - A natural product from Andrographis paniculata nees

Ricky Emery Kamdem, Shengmin Sang, Chi-Tang Ho

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

It was hypothesized that neoandrographolide might scavenge free radicals by donating the allylic hydrogen of the unsaturated lactone ring. It was found that the stoichiometry of the reaction between neoandrographolide and superoxide radical generated from KO2 in DMSO was 2 to 1. One major reaction product was isolated and determined to be a diacid formed by the opening of the lactone ring. It was concluded that the antiradical activity of neoandrographolide proceeded by hydrogen abstraction from carbon C-15. A reaction mechanism was proposed.

Original languageEnglish (US)
Pages (from-to)4662-4665
Number of pages4
JournalJournal of agricultural and food chemistry
Volume50
Issue number16
DOIs
StatePublished - Jul 31 2002

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Andrographis paniculata
  • Antiradical activity
  • Diterpene lactone
  • Neoandrographolide
  • Superoxide radical

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