Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics

Konstantin A. Demin, Aleksandr G. Refeld, Anna A. Bogdanova, Evgenya V. Prazdnova, Igor V. Popov, Olga Yu Kutsevalova, Alexey M. Ermakov, Anzhelica B. Bren, Dmitry V. Rudoy, Vladimir A. Chistyakov, Richard Weeks, Michael L. Chikindas

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

Original languageEnglish (US)
Pages (from-to)926-948
Number of pages23
JournalProbiotics and Antimicrobial Proteins
Volume13
Issue number4
DOIs
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Medicine
  • Molecular Biology

Keywords

  • Antifungal drugs
  • Biofilm formation
  • Candida
  • Probiotics
  • Resistance

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