TY - JOUR
T1 - Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It
T2 - The Role of Probiotics
AU - Demin, Konstantin A.
AU - Refeld, Aleksandr G.
AU - Bogdanova, Anna A.
AU - Prazdnova, Evgenya V.
AU - Popov, Igor V.
AU - Kutsevalova, Olga Yu
AU - Ermakov, Alexey M.
AU - Bren, Anzhelica B.
AU - Rudoy, Dmitry V.
AU - Chistyakov, Vladimir A.
AU - Weeks, Richard
AU - Chikindas, Michael L.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/8
Y1 - 2021/8
N2 - Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.
AB - Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.
KW - Antifungal drugs
KW - Biofilm formation
KW - Candida
KW - Probiotics
KW - Resistance
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U2 - 10.1007/s12602-021-09776-6
DO - 10.1007/s12602-021-09776-6
M3 - Review article
C2 - 33738706
AN - SCOPUS:85103069091
SN - 1867-1306
VL - 13
SP - 926
EP - 948
JO - Probiotics and Antimicrobial Proteins
JF - Probiotics and Antimicrobial Proteins
IS - 4
ER -