Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics

Konstantin A. Demin; Aleksandr G. Refeld; Anna A. Bogdanova; Evgenya V. Prazdnova; Igor V. Popov; Olga Yu Kutsevalova; Alexey M. Ermakov; Anzhelica B. Bren; Dmitry V. Rudoy; Vladimir A. Chistyakov; Richard Weeks; Michael L. Chikindas

doi:10.1007/s12602-021-09776-6

Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics

Konstantin A. Demin, Aleksandr G. Refeld, Anna A. Bogdanova, Evgenya V. Prazdnova, Igor V. Popov, Olga Yu Kutsevalova, Alexey M. Ermakov, Anzhelica B. Bren, Dmitry V. Rudoy, Vladimir A. Chistyakov, Richard Weeks, Michael L. Chikindas

School of Environmental and Biological Sciences, Food Science

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

Original language	English (US)
Pages (from-to)	926-948
Number of pages	23
Journal	Probiotics and Antimicrobial Proteins
Volume	13
Issue number	4
DOIs	https://doi.org/10.1007/s12602-021-09776-6
State	Published - Aug 2021

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Medicine
Molecular Biology

Keywords

Antifungal drugs
Biofilm formation
Candida
Probiotics
Resistance

Access to Document

10.1007/s12602-021-09776-6

Cite this

Demin, K. A., Refeld, A. G., Bogdanova, A. A., Prazdnova, E. V., Popov, I. V., Kutsevalova, O. Y., Ermakov, A. M., Bren, A. B., Rudoy, D. V., Chistyakov, V. A., Weeks, R., & Chikindas, M. L. (2021). Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics. Probiotics and Antimicrobial Proteins, 13(4), 926-948. https://doi.org/10.1007/s12602-021-09776-6

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title = "Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics",

abstract = "Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.",

keywords = "Antifungal drugs, Biofilm formation, Candida, Probiotics, Resistance",

author = "Demin, {Konstantin A.} and Refeld, {Aleksandr G.} and Bogdanova, {Anna A.} and Prazdnova, {Evgenya V.} and Popov, {Igor V.} and Kutsevalova, {Olga Yu} and Ermakov, {Alexey M.} and Bren, {Anzhelica B.} and Rudoy, {Dmitry V.} and Chistyakov, {Vladimir A.} and Richard Weeks and Chikindas, {Michael L.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2021",

month = aug,

doi = "10.1007/s12602-021-09776-6",

language = "English (US)",

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Demin, KA, Refeld, AG, Bogdanova, AA, Prazdnova, EV, Popov, IV, Kutsevalova, OY, Ermakov, AM, Bren, AB, Rudoy, DV, Chistyakov, VA, Weeks, R & Chikindas, ML 2021, 'Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics', Probiotics and Antimicrobial Proteins, vol. 13, no. 4, pp. 926-948. https://doi.org/10.1007/s12602-021-09776-6

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T1 - Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It

T2 - The Role of Probiotics

AU - Demin, Konstantin A.

AU - Refeld, Aleksandr G.

AU - Bogdanova, Anna A.

AU - Prazdnova, Evgenya V.

AU - Popov, Igor V.

AU - Kutsevalova, Olga Yu

AU - Ermakov, Alexey M.

AU - Bren, Anzhelica B.

AU - Rudoy, Dmitry V.

AU - Chistyakov, Vladimir A.

AU - Weeks, Richard

AU - Chikindas, Michael L.

PY - 2021/8

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N2 - Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

AB - Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

KW - Antifungal drugs

KW - Biofilm formation

KW - Candida

KW - Probiotics

KW - Resistance

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