The history of pharmaceutical sciences is replete with examples of attempts at increasing in drug efficacy and overcoming drug resistance. These attempts have contributed substantially to our knowledge about cellular defensive mechanisms and methods to overcome them. The present chapter aims at describing the main cellular mechanisms of drug resistance and the most well-known approaches for their suppression. This field is vast and therefore the focus will be restricted to anticancer and antimicrobial drugs.
|Original language||English (US)|
|Title of host publication||Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids|
|Number of pages||32|
|State||Published - Jan 1 2004|
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)