Mechanisms of cellular drug resistance and strategies to overcome it

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The history of pharmaceutical sciences is replete with examples of attempts at increasing in drug efficacy and overcoming drug resistance. These attempts have contributed substantially to our knowledge about cellular defensive mechanisms and methods to overcome them. The present chapter aims at describing the main cellular mechanisms of drug resistance and the most well-known approaches for their suppression. This field is vast and therefore the focus will be restricted to anticancer and antimicrobial drugs.

Original languageEnglish (US)
Title of host publicationBiomaterials for Delivery and Targeting of Proteins and Nucleic Acids
PublisherCRC Press
Pages461-492
Number of pages32
ISBN (Electronic)9780203492321
ISBN (Print)9780849323348
StatePublished - Jan 1 2004

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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