Mechanistic modeling of inflammation

Jeremy D. Scheff, Kubra Kamisoglu, Ioannis P. Androulakis

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


In this chapter we explore the characteristics underlying the development of mechanistic-based models of inflammation. The discussion covers the three basic arms of developing mechanistic models. We begin by exploring the likely experimental analogues producing critical information, we then review modeling alternatives for representing the biological system under study, and finally we review the key methods for executing the model and performing the required calculation. The discussion concludes with a brief overview of the challenges and opportunities in the context of bridging the gap between (mechanistic) disease and pharmacology models as we move towards more integrated systems pharmacology approaches with the ultimate goal of designing relevant in silico clinical trials enabling rational extrapolation of bench observations.

Original languageEnglish (US)
Title of host publicationAAPS Advances in the Pharmaceutical Sciences Series
PublisherSpringer Verlag
Number of pages28
StatePublished - 2016

Publication series

NameAAPS Advances in the Pharmaceutical Sciences Series
ISSN (Print)2210-7371
ISSN (Electronic)2210-738X

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


  • Bioinformatics
  • Clinical trials
  • Cross-system interactions
  • Disease progression
  • Homeostasis
  • Immunomodulatory signals
  • In silico
  • In vitro models
  • Lumped
  • Phenomenological
  • Quasi-mechanistic
  • Statistical
  • Stochasticity


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