Mechanochemical-hydrothermal synthesis of calcium phosphate powders with coupled magnesium and carbonate substitution

Wojciech L. Suchanek; Kullaiah Byrappa; Pavel Shuk; Richard E. Riman; Victor F. Janas; Kevor S. Tenhuisen

doi:10.1016/j.jssc.2003.09.012

Mechanochemical-hydrothermal synthesis of calcium phosphate powders with coupled magnesium and carbonate substitution

Wojciech L. Suchanek, Kullaiah Byrappa, Pavel Shuk, Richard E. Riman, Victor F. Janas, Kevor S. Tenhuisen

School of Engineering, Materials Science & Engineering

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Magnesium- and carbonate-substituted calcium phosphate powders (Mg-, CO₃-CaP) with various crystallinity levels were prepared at room temperature via a heterogeneous reaction between MgCO₃/Ca(OH) ₂ powders and an (NH₄)₂HPO₄ solution using the mechanochemical-hydrothermal route. X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis were performed. It was determined that the powders containing both Mg²⁺ and CO ₃^2- ions were incorporated uniformly into an amorphous calcium phosphate phase while in contrast, the as-prepared powder free of these dopants was crystalline phase-pure, stoichiometric hydroxyapatite. Dynamic light scattering revealed that the average particle size of the room temperature Mg-, CO₃-CaP powders was in the range of 482nm-700nm with a specific surface area between 53 and 91m²/g. Scanning electron microscopy confirmed that the Mg-, CO₃-CaP powders consisted of agglomerates of equiaxed, ≈20-35nm crystals.

Original language	English (US)
Pages (from-to)	793-799
Number of pages	7
Journal	Journal of Solid State Chemistry
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.jssc.2003.09.012
State	Published - Mar 2004

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Condensed Matter Physics
Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Keywords

Calcium phosphate
Hydrothermal Synthesis
Hydroxyapatite
Magnesium
Mechanochemical synthesis
Nanoparticle

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10.1016/j.jssc.2003.09.012

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title = "Mechanochemical-hydrothermal synthesis of calcium phosphate powders with coupled magnesium and carbonate substitution",

abstract = "Magnesium- and carbonate-substituted calcium phosphate powders (Mg-, CO3-CaP) with various crystallinity levels were prepared at room temperature via a heterogeneous reaction between MgCO3/Ca(OH) 2 powders and an (NH4)2HPO4 solution using the mechanochemical-hydrothermal route. X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis were performed. It was determined that the powders containing both Mg2+ and CO 32- ions were incorporated uniformly into an amorphous calcium phosphate phase while in contrast, the as-prepared powder free of these dopants was crystalline phase-pure, stoichiometric hydroxyapatite. Dynamic light scattering revealed that the average particle size of the room temperature Mg-, CO3-CaP powders was in the range of 482nm-700nm with a specific surface area between 53 and 91m2/g. Scanning electron microscopy confirmed that the Mg-, CO3-CaP powders consisted of agglomerates of equiaxed, ≈20-35nm crystals.",

keywords = "Calcium phosphate, Hydrothermal Synthesis, Hydroxyapatite, Magnesium, Mechanochemical synthesis, Nanoparticle",

author = "Suchanek, {Wojciech L.} and Kullaiah Byrappa and Pavel Shuk and Riman, {Richard E.} and Janas, {Victor F.} and Tenhuisen, {Kevor S.}",

note = "Funding Information: This research was supported by the Johnson & Johnson Center for Biomaterials and Advanced Technologies, the Center for Biomedical Devices at Rutgers University, and the National Institute of Health. The authors are greatly indebted to James Kim for experimental assistance, Eric Gulliver and Mohit Jain for obtaining the FESEM images.",

year = "2004",

month = mar,

doi = "10.1016/j.jssc.2003.09.012",

language = "English (US)",

volume = "177",

pages = "793--799",

journal = "Journal of Solid State Chemistry",

issn = "0022-4596",

publisher = "Academic Press Inc.",

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AU - Suchanek, Wojciech L.

AU - Byrappa, Kullaiah

AU - Shuk, Pavel

AU - Riman, Richard E.

AU - Janas, Victor F.

AU - Tenhuisen, Kevor S.

N1 - Funding Information: This research was supported by the Johnson & Johnson Center for Biomaterials and Advanced Technologies, the Center for Biomedical Devices at Rutgers University, and the National Institute of Health. The authors are greatly indebted to James Kim for experimental assistance, Eric Gulliver and Mohit Jain for obtaining the FESEM images.

PY - 2004/3

Y1 - 2004/3

N2 - Magnesium- and carbonate-substituted calcium phosphate powders (Mg-, CO3-CaP) with various crystallinity levels were prepared at room temperature via a heterogeneous reaction between MgCO3/Ca(OH) 2 powders and an (NH4)2HPO4 solution using the mechanochemical-hydrothermal route. X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis were performed. It was determined that the powders containing both Mg2+ and CO 32- ions were incorporated uniformly into an amorphous calcium phosphate phase while in contrast, the as-prepared powder free of these dopants was crystalline phase-pure, stoichiometric hydroxyapatite. Dynamic light scattering revealed that the average particle size of the room temperature Mg-, CO3-CaP powders was in the range of 482nm-700nm with a specific surface area between 53 and 91m2/g. Scanning electron microscopy confirmed that the Mg-, CO3-CaP powders consisted of agglomerates of equiaxed, ≈20-35nm crystals.

AB - Magnesium- and carbonate-substituted calcium phosphate powders (Mg-, CO3-CaP) with various crystallinity levels were prepared at room temperature via a heterogeneous reaction between MgCO3/Ca(OH) 2 powders and an (NH4)2HPO4 solution using the mechanochemical-hydrothermal route. X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis were performed. It was determined that the powders containing both Mg2+ and CO 32- ions were incorporated uniformly into an amorphous calcium phosphate phase while in contrast, the as-prepared powder free of these dopants was crystalline phase-pure, stoichiometric hydroxyapatite. Dynamic light scattering revealed that the average particle size of the room temperature Mg-, CO3-CaP powders was in the range of 482nm-700nm with a specific surface area between 53 and 91m2/g. Scanning electron microscopy confirmed that the Mg-, CO3-CaP powders consisted of agglomerates of equiaxed, ≈20-35nm crystals.

KW - Calcium phosphate

KW - Hydrothermal Synthesis

KW - Hydroxyapatite

KW - Magnesium

KW - Mechanochemical synthesis

KW - Nanoparticle

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Mechanochemical-hydrothermal synthesis of calcium phosphate powders with coupled magnesium and carbonate substitution

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